Highlights:
- Neurizon has successfully developed a new oral liquid formulation of NUZ-001 for the treatment of ALS
- The liquid formulation is designed to support patients with all stages of ALS, particularly those with swallowing difficulties such as bulbar onset, ensuring broader access to therapy
- Developed as part of Neurizon’s patient-centric innovation strategy, the liquid form enhances continuation of treatment, ease of administration, and overall treatment experience for patients with ALS
- Supports Neurizon’s life cycle management strategy to transform NUZ-001 from a single-asset product into a long-term scalable treatment platform and unlock patient and commercial value
- Integration into Neurizon’s ongoing clinical development program for NUZ-001 has commenced, with a human bioequivalence study alongside the standard tablet form, scheduled to begin in H1 CY 2026
MELBOURNE, Australia, June 27, 2025 / Biotech Newswire / -- Neurizon® Therapeutics Limited (ASX: NUZ & NUZOA) (“Neurizon” or “the Company”), a clinical-stage biotech company dedicated to advancing innovative treatments for neurodegenerative diseases, is pleased to announce the development of a new oral liquid formulation of NUZ-001, its lead investigational therapy for the treatment of Amyotrophic Lateral Sclerosis (ALS). This advancement represents a significant step toward improving accessibility, ease of administration, and overall treatment experience for patients living with ALS.
The newly developed oral liquid formulation reflects Neurizon’s commitment to innovation that addresses the real-world challenges faced by people affected by ALS. For many patients, especially those experiencing bulbar onset or progressive difficulty swallowing, tablet-based medication can become increasingly hard to manage as the disease advances. The oral liquid formulation provides an important alternative, ensuring more patients can continue to benefit from NUZ-001 throughout their journey.
Developed in direct response to feedback from patients and carers, this formulation reflects Neurizon’s belief that the patient voice should guide both trial design and treatment delivery. The key advantages of the liquid formulation include:
- Improved ease of swallowing for patients with dysphagia or speech impairment
- Flexible dosing across a range of patient weights and tolerances
- Enteral (feeding tube) administration, ensuring continuity of treatment
- Simplified administration for caregivers and clinical teams
Dr Michael Thurn, Managing Director and Chief Executive Officer, commented: “As ALS progresses, patients face increasing challenges with day-to-day activities, including something as fundamental as swallowing. This innovation is about flexibility, inclusion, and staying aligned with the needs of people living with ALS. Developing a successful oral liquid formulation - especially for a therapeutic like NUZ-001 targeting a vulnerable patient population - requires careful consideration of physical, chemical, and compatibility factors to ensure stability, bioavailability, and patient usability. By offering NUZ-001 in a liquid form, we’re ensuring that more patients can benefit from the therapy throughout all stages of disease progression.”
The development of the liquid formulation also marks the launch of a life cycle management (LCM) strategy for NUZ-001. LCM transforms a drug from a single-asset product into a long-term, scalable treatment platform, enhancing both patient value and commercial success. By strategically evolving the product, Neurizon aims to maximise patient impact, support long-term commercial growth, and drive innovation well beyond the original patent expiry.
Next Steps
The liquid formulation is currently being integrated into Neurizon’s ongoing clinical development program for NUZ-001 and will be evaluated for bioequivalence and patient acceptability alongside the standard tablet form. This human bioequivalence study is scheduled to commence in H1 CY 2026.
Neurizon remains committed to advancing accessible, patient-informed therapeutic solutions that reflect the lived experience of those affected by ALS.
About Neurizon Therapeutics Limited
Neurizon Therapeutics Limited (ASX: NUZ) is a clinical-stage biotechnology company dedicated to advancing treatments for neurodegenerative diseases. Neurizon is developing its lead drug candidate, NUZ-001, for the treatment of ALS, which is the most common form of motor neurone disease. Neurizon’s strategy is to accelerate access to effective ALS treatments for patients while exploring the potential of NUZ-001 for broader neurodegenerative applications. Through international collaborations and rigorous clinical programs, Neurizon is dedicated to creating new horizons for patients and families impacted by complex neural disorders.
Neurizon® is a registered trademark of Neurizon Therapeutics Limited
This announcement has been authorized for release by the Board of Neurizon Therapeutics Limited.
Contacts
Neurizon Therapeutics Limited
Dr. Michael Thurn
Managing Director and Chief Executive Officer
This email address is being protected from spambots. You need JavaScript enabled to view it.
+61 (3) 9692 7222
Lidija Damjanovic
Head of Marketing and Corporate Affairs
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+61 (0) 425 700 504
Keywords: Amyotrophic Lateral Sclerosis; Deglutition Disorders; Deglutition; Neurodegenerative Diseases; Therapies, Investigational; Speech Disorders; Biotechnology; Neurizon Therapeutics; NUZ-001; oral liquid formulation; swallowing difficulties; bulbar onset; patient-centric innovation; ease of administration; treatment accessibility; life cycle management (LCM); scalable treatment platform; tablet vs. liquid formulation; dysphagia; feeding tube administration; flexible dosing; patient usability; neurodegenerative diseases; motor neurone disease; caregiver support;
Source: Biotech Newswire