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University of Liverpool to Use Touchlight’s Rapid Enzymatic dbDNA in Fully Personalised Neoantigen Cancer Vaccine Clinical Study

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The UK’s Medical Research Council is funding a 10-patient Phase I study to deliver rapid personalised treatment for lung cancer patients.

HAMPTON, UK, April 03, 2024 / Biotech Newswire / -- Touchlight, a CDMO enabling the development of genetic medicines with its enzymatic doggybone DNA (dbDNA™) technology, today announced an agreement with University of Liverpool for the use of dbDNA in the development of a fully-personalised therapeutic neoantigen DNA vaccine for patients with non-small cell lung cancer, to be given to patients at Clatterbridge Cancer Center, Liverpool.

Non-small cell lung cancer is the most common type of lung cancer, with almost 50,000 new diagnoses each year. It is the third most prevalent cancer in the UK and, globally, it is estimated that there were 2.2million new cases in 2020 alone.

The University of Liverpool researchers will be conducting a clinical trial that involves making a personalised cancer vaccine for each patient. The approach is designed to train the patient’s own immune system by targeting mutations in patients’ individual cancer and support patients who have not had sufficient benefit from standard immunotherapy.

Touchlight’s dbDNA technology produces a minimal, linear, double stranded, covalently closed DNA vector through an enzymatic manufacturing process.

dbDNA technology can deliver high purity GMP DNA in a small footprint at unprecedented speed and is ideally positioned to enable rapid individual personalised vaccines to cancer patients.


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Prof. Christian Ottensmeier, Chief investigator and shared lead of the project of the study said: "We are delighted to work with Touchlight on developing this trial. The dbDNA approach offers a way to make vaccines very quickly, including for personalised treatments. We are very excited that we will be able to offer this clinical trial to patients with advanced lung cancer in Liverpool and expect that patients can be included starting in the 2nd half of 2024."

Prof. Natalia Savelyeva, joint lead of the study added: "This trials results from a long-standing collaboration between our team and Touchlight. The vaccine platform is completely novel and we believe has enormous promise in providing cancer vaccines that need to be made for each individual patient”.

Karen Fallen, CEO, Touchlight commented: “We are delighted to be able to support the Liverpool team in the development of such an innovative therapeutic approach. Christian and his team are world-leaders in cancer immunology, and we are proud that our dbDNA technology is able to provide an improved turnaround time for a patient group with extremely high unmet need.


About Touchlight
Touchlight is a privately-owned innovation-driven CDMO based in London, U.K., focused on the provision of DNA services and manufacture of enzymatically produced doggybone DNA (dbDNA™) to enable the development of genetic medicines. Touchlight provides rapid, enzymatic DNA development and manufacturing for all advanced therapy production, including mRNA, viral and non-viral gene therapy and DNA API. dbDNA is a minimal, linear, covalently closed structure, which eliminates bacterial sequences. Touchlight’s revolutionary enzymatic production platform enables unprecedented speed, scale, and the ability to target genes with a size and complexity that is impossible with current technologies. Clients can be supported from pre-clinical through development and supply, to licencing and tech transfer for use in-house.



Karen Fallen, Chief Executive Officer
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+44 20 8481 9200


Keywords: Manufacturing Industry; Vaccines, DNA; RNA, Messenger; Gene Editing; DNA; RNA; Technology; United Kingdom; University of Liverpool; Touchlight; Enzymatic dbDNA; Personalized neoantigen cancer vaccine; Clinical study; Phase I study; Lung cancer; Clatterbridge Cancer Center; Non-small cell lung cancer; Immunotherapy; GMP DNA; Prof. Christian Ottensmeier; Prof. Natalia Savelyeva; Cancer immunology; Genetic medicines; CDMO (Contract Development and Manufacturing Organization); Doggybone DNA (dbDNA™); Enzymatic manufacturing process; Minimal DNA; Linear DNA; Rapid individual personalized vaccines; High purity DNA; mRNA; Viral and non-viral gene therapy; DNA API; Bacterial sequences; Enzymatic production platform; Licensing; Tech transfer; Genetic medicine development

Published by Biotech Newswire

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